www.PCOSTreatmentReport.com
https://clinicaltrials.gov/ct2/show/NCT03898934?recrs=abdf&type=Intr&cond=Polycystic+Ovary+Syndrome&lupd_s=03%2F19%2F2019&lupd_d=14
Condition : PCOS
Interventions : Drug: Vitamin D; Drug: Placebo Oral Tablet
Sponsor : Tanta University
Not yet recruiting
Vitamin D Supplementation in Lean PCOS Patients
NCT03898934
Tue, 02 Apr 2019 12:00:00 EDT
Last Update Posted: 04/02/19 08:08AM
https://www.ncbi.nlm.nih.gov/pubmed/31091067?dopt=Abstract
https://www.nature.com/articles/s41598-019-40653-z
https://www.ncbi.nlm.nih.gov/pubmed/30850700?dopt=Abstract
Related Articles
Association Between Vitamin D and Adrenal Parameters with Metabolic and Inflammatory Markers in Polycystic Ovary Syndrome.
Sci Rep. 2019 Mar 08;9(1):3968
Authors: Maidana P, Fritzler A, Mocarbel Y, Perez Lana MB, González D, Rosales M, González de Chazal F, Sternberg K, Lamas Majek E, Mallea-Gil S, Genovesi E, Pelayo M, Fabre B, Mesch V
Abstract
Vitamin D deficiency has been related with metabolic alterations in polycystic ovary syndrome (PCOS). As well, hyperactivation of adrenal axis can be programmed early in life and could be related later with PCOS development. Our aim was to establish the relationship between vitamin D and adrenal parameters with metabolic alterations and inflammation markers in PCOS. In 73 patients and 33 controls, 25-hydroxyvitamin D (25-OH-D), total and bioavailable testosterone (TT and bioT), androstenedione (A4), SHBG, cortisol, insulin, and C-reactive protein (hs-CRP) were determined; HOMA and lipid accumulation product (LAP) index were calculated. All parameters were higher in patients than in controls, except for SHBG and 25-OH-D which were lower. Binary regression analysis showed that differences in TT, bioT, A4, insulin and HOMA were independent of body mass index and waist circumference but SHBG, hs-CRP, LAP and 25-OH-D were related to body weight and fat distribution. Binary logistic regression analysis showed that cortisol and 25-OH-D could be associated to PCOS development. Correlations found between LAP and insulin, HOMA and hs-CRP confirm it is a good indicator of metabolic complications. Vitamin D and cortisol association to PCOS development justifies future research to understand the role of vitamin D in PCOS and analyze patient’s perinatal history and its possible relationship with hyperactivation of adrenal axis in adult life.
PMID: 30850700 [PubMed – in process]
https://www.ncbi.nlm.nih.gov/pubmed/30170183?dopt=Abstract
https://www.sciencedirect.com/science/article/pii/S0303720718302533
Related Articles
Crosstalk between advanced glycation end products and vitamin D: A compelling paradigm for the treatment of ovarian dysfunction in PCOS.
Mol Cell Endocrinol. 2019 01 05;479:20-26
Authors: Merhi Z
Abstract
Women with PCOS have elevated levels of the harmful advanced glycation end products (AGEs) and low serum levels of vitamin D. AGEs and their receptors may contribute to the pathogenesis of PCOS and its metabolic and reproductive consequences. On the other hand, vitamin D might improve PCOS phenotype and could alleviate the detrimental effects of AGEs. A literature review using PubMed was performed. Critical analysis was carried out for articles pertaining to: 1) the role of AGEs and their receptors in the pathophysiology of PCOS, in particular ovarian dysfunction, and 2) the action of vitamin D in attenuating the adverse effects of AGEs in women with PCOS at both the serum and the cellular levels. Data from in vitro experiments, animal models, and human studies provide compelling evidence that AGEs and their receptors may contribute to the pathogenesis of ovarian dysfunction in PCOS. The actions of AGEs in PCOS might be attenuated and/or reversed by the presence or supplementation of vitamin D. Once a mechanistic understanding of the relationship between AGEs and vitamin D is established, this knowledge might contribute to the subsequent development of new-targeted pharmacological therapies for improving ovarian health in women with PCOS.
PMID: 30170183 [PubMed – indexed for MEDLINE]
